http://www.red-gate.com/Products/ants_profiler/index.htm
http://www.yourkit.com/
http://msmvps.com/blogs/theproblemsolver/archive/2006/09/25/Red-Gate-_2D00_-ANTS-Profiler.aspx

With YourKit solutions, both CPU and memory profiling have come to the highest professional level, where one can profile even huge applications with maximum productivity and zero overhead.